Lateral Movement in Windows Systems and Detecting the Undetected ShadowMove

Lateral Movement is a pervasive threat that exists because modern networked systems that provide access to multiple users are far more efficient than their non-networked counterparts. It is a well-known attack methodology with extensive research completed into preventing lateral movement in enterprise systems. However, attackers are using more sophisticated methods to move laterally that bypass typical detection systems. This research comprehensively reviews the problems in lateral movement detection and outlines common defenses to protect modern systems from lateral movement attacks. A literature review is conducted, outlining new techniques for automatic detection of malicious lateral movement, explaining common attack methods utilized by Advanced Persistent Threats, and components built into the Windows operating system that can assist with discovering malicious lateral movement. Finally, a novel method for moving laterally is introduced and studied, and an original method for detecting this method of lateral movement is proposed

A Novel Method for Moving Laterally and Discovering Malicious Lateral Movements in Windows Operating Systems: A Case Study

Lateral movement is a pervasive threat because modern networked systems that provide access to multiple users are far more efficient than their non-networked counterparts. It is a well-known attack methodology with extensive research conducted investigating the prevention of lateral movement in enterprise systems. However, attackers use increasingly sophisticated methods to move laterally that bypass typical detection systems. This research comprehensively reviews the problems in lateral movement detection and outlines common defenses to protect modern systems from lateral movement attacks. A literature review outlines techniques for automatic detection of malicious lateral movement, explaining common attack methods utilized by advanced persistent threats and components built into the Windows operating system that can assist with discovering malicious lateral movement. Finally, a novel approach for moving laterally designed by other security researchers is reviewed and studied, an original process for detecting this method of lateral movement is proposed, and the application of the detection methodology is also expanded

Plant functional traits suggest novel ecological strategy for an invasive shrub in an understorey woody plant community

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/86864/1/j.1365-2664.2011.02049.x.pd

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707